The Rhône wine region in Southern France is situated in the Rhône valley and produces numerous wines under various Appellation d'origine contrôlée (AOC) designations. The region's major appellation in production volume is Côtes du Rhône AOC.

The Rhône is generally divided into two sub-regions with distinct vinicultural traditions, the Northern Rhône (referred to in French as Rhône septentrional) and the Southern Rhône (in French Rhône méridional). The northern sub-region produces red wines from the Syrah grape, sometimes blended with white wine grapes, and white wines from Marsanne, Roussane and Viognier grapes. The southern sub-region produces an array of red, white and rosé wines, often blends of several grapes such as in Châteauneuf-du-Pape.

The various AOC wines of the Rhône Valley region are produced by over 6,000 wine growing properties including 1,837 private wineries and 103 cooperatives.[4] Those vineyard owners which do not vinify their wines themselves deliver their grapes in bulk either to a winemaking cooperative, of which there are 103 in the region, or sell them to one of the 51 négociants (wine producers and merchants) who blend, distribute, and export on an industrial scale.

The entire Rhône region produces around 4 million hl of wine each year, of which over half is classified under the Côte du Rhône and Côte du Rhône-Villages appellations. The prestigious Northern Rhône appellations account for less than 5% of the total Rhône wine production.